Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques
The World Journal of Men's Health
;
: 148-156, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-742363
ABSTRACT
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict fertilization. Sperm genetic components could play an important role in the early stages of embryonic development. Based on these acquisitions, several epigenetic investigations have been developed on spermatozoa, with the aim of understanding the multifactorial etiology of male infertility and of showing whether embryonic development may be influenced by sperm epigenetic abnormalities. This article reviews the possible epigenetic modifications of spermatozoa and their effects on male fertility, embryonic development and ART outcome. It focuses mainly on sperm DNA methylation, chromatin remodeling, histone modifications and RNAs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Spermatozoïdes
/
ARN
/
Méthylation de l'ADN
/
Techniques de reproduction assistée
/
Assemblage et désassemblage de la chromatine
/
Code histone
/
Développement embryonnaire
/
Fécondité
/
Fécondation
/
Épigénomique
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Mâle
/
Grossesse
langue:
Anglais
Texte intégral:
The World Journal of Men's Health
Année:
2019
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS