Neuroprotective effect and mechanisms of Homer1a:research advances / 国际药学研究杂志

ABSTRACT

Homer1a, encoded by immediate early genes (IEG), is a scaffold protein of post-synaptic density, which is widely expressed in the central nervous system. Homer1a overexpression has been found in many neuropsychiatric disorders, and its regulatory signal transduction plays an important role in synaptic plasticity and neuroprotection, which has gradually become a research focus. The research and development of the neuroprotective drugs targeting Homer1a has also attracted a great attention. In addition, studies in recent years have showed that the development and treatment of neurological diseases are correlated with the Homer1a level.This article reviews the basic structural characteristics of Homer1a, its protective effect on the schizophrenia, depression and epilepsy as well as the neuroprotective mechanism of Homer1a based on the latest research reports.