Recent advances in regulatory effects of microRNA in thyroid-associated ophthalmopathy / 中华实验眼科杂志

ABSTRACT

MicroRNAs (miRNAs) are endogenous,single-stranded,noncoding RNAs with 18 to 24 nucleotides in length.miRNAs play important regulatory roles by targeting mRNAs for cleavage or translational repression.Thus,they negatively regulate gene expression at the post-transcriptional level.miRNA can degrade target mRNA or inhibit the translational level of their target mRNAs,which in turn affects cell differentiation,proliferation and apoptosis,and thus plays an important role in the regulation in the occurrence of diseases and the development of the organism.Recent studies have shown that miRNA also plays an important regulatory role in the development of thyroid-associated ophthalmopathy (TAO).This article reviewed the regulatory effect of miRNA in the development of TAO,providing a new insight in the pathogenesis and treatment of TAO.