Relationship between hs - CRP and the etiology of children with hand - foot - and - mouth disease / 中国基层医药

ABSTRACT

Objective To explore the relationship between hs - CRP and the etiology of children with hand- foot - and - mouth disease(HFMD). Methods A total of 1156 laboratory - confirmed children diagnosed with HFMD by pathogenic detection(detection methods include EV71 - CA16 IgM antibody detection and universal real -time fluorescent quantitative RT - PCR detection of enterovirus nucleic acid EV71/ CA16/ EV) in the Children′s Hospital of Hangzhou were involved in the research from September 2014 to July 2016. The hs - CRP levels in the early days(≤5 days) were recorded,and all data were analyzed with SPSS16. 0. Results Of all the 1156 cases,there were 642 cases with hs - CRP level more than 10mg/ dL,of whom 37 cases were infected by EV71(5. 8％ ),552 cases were infected by EV(86. 0％ ),53 cases were infected by CA16(8. 2％ ). In 514 cases with hs - CRP level less than 10mg/ dL,of whom 298 cases were infected by EV71(58. 0％ ),152 cases were infected by EV(29. 6％ ),64 cases were infected by CA16(12.4％). Of cases with hs - CRP >10mg/ dL,EV universal type got a significantly higher rate,with statistically significant difference(P < 0. 05). Of cases with hs - CRP < 10mg/ dL,EV71 got a significantly higher rate,with statistically significant difference(P < 0. 05). Conclusion The higher the hs - CRP level of the HFMD,the higher infection rate of EV. The lower the hs - CRP level of the HFMD,the higher infection rate of EV71.