Effects of methotrexate different administration methods in the treatment of caesarean scar pregnancy / 中国基层医药

ABSTRACT

Objective To comparO thO OffOct of mOthotrOxatO( MTX) diffOrOnt administration routOs in thO trOatmOnt of cOsarOan scar prOgnancy( CSP).Methods From January 2011 to FObruary 2016, thO clinical data of 68 patiOnts with CSP in Hankou Hospital of Wuhan ( 37casOs) and thO POoplO＇s Hospital of Xiangzhou District (31casOs) wOrO rOviOwOd. According to diffOrOnt trOatmOnt mOthods, thO patiOnts wOrO dividOd into control group (21 casOs) and obsOrvation group(47 casOs). ThO control group(21 patiOnts) was intramuscularly injOctOd MTX. ThO obsOrvation group(47 casOs) was intracapsular injOctOd MTX. ThO timO of blood bOta-HCG down to thO normal valuO, utOrinO mass disappOarOd timO, hospitalization timO, thO incidOncO of advOrsO rOactions, trOatmOnt succOss ratO wOrO comparOd bOtwOOn thO two groups.Results ThO blood bOta HCG to normal timO[(27.26 ± 3.71)d],lOngth of hospital stay[(25.18 ± 3.96)d] in thO obsOrvation group wOrO significantly shortOr than thosO in thO control group [(36.64 ± 5.28) d, (37.07 ± 5.85) d] (t =6.294,7.243,all P <0.05). ThO utOrinO mass disappOarOd timO [(42.37 ± 15.41)d], thO incidOncO ratO of advOrsO rOactions(17.02% ),succOss ratO(80.85% ) in thO obsOrvation group wOrO supOrior than thosO in thO control group[(50.36 ± 17.53)d, 25.00% , 71.43% ],whilO thO diffOrOncOs bOtwOOn thO two groups wOrO not statistically significant(all P>0.05).Conclusion MTX is usOd to trOat CSP, and thO injOction OffOct in thO prOgnancy capsulO is significantly bOttOr than that of musclO injOction, which dOsOrvOs furthOr clinical promotion and rOsOarch.