Expression of BDNF mRNA in nasal mucosa with allergic rhinitis rat model / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To evaluate the role of brain-derived neurotrophic factor (BDNF) in allergic rhinitis of rat.@*METHOD@#Thirty SD rats free of disease were randomly divided into two groups. A model of allergic rhinitis rat was established by using ovalbumin intraperitoneal immunization and intranasal antigen challenge. The nasal mucosa from 18 out of 20 AR models as well as 10 normal controls were studied for expression of BDNF mRNA by reverse transcription-polymerase chain reaction (RT-PCR).@*RESULT@#BDNF/beta-actin ratio in AR models was significantly higher than control (0.49+/-0.07 vs 0.28+/-0.01, P<0.05).@*CONCLUSION@#BDNF played an important role in the development of allergic rhinitis of rat.