Stat3 antisense oligodeoxynucleotide induces apoptosis in laryngeal carcinoma cells by regulating apoptosis-related factors / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 155-157, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-746652
ABSTRACT
OBJECTIVE@#To study the mechanism of apoptosis in laryngeal carcinoma cell induced by Stat3 antisense oligodeoxynucleotide (ASODN).@*METHOD@#The designed Stat3 ASODN was transferred into laryngeal carcinoma Hep-2 cell by lipofection. Expression of Bcl-2, Bax and C-Myc were detected by Western blot and PCR.@*RESULT@#Western blot and PCR results demonstrated that Stat3 ASODN could significantly increased the expression of Bax and decreased the expression of Bcl-2 and C-Myc when the concentration of antisense oligodeoxynucleotide were heightened.@*CONCLUSION@#Stat3 ASODN participate in apoptosis by enhancing the expression of Bax and reducing the expression of Bcl-2 and C-Myc.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Régulation de l'expression des gènes tumoraux
/
Protéines proto-oncogènes c-myc
/
Apoptose
/
Protéines proto-oncogènes c-bcl-2
/
Oligodésoxyribonucléotides antisens
/
Lignée cellulaire tumorale
/
Facteur de transcription STAT-3
/
Protéine Bax
/
Génétique
/
Métabolisme
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Année:
2010
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS