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The effect of oxidative stress on aorta endothelial cell in chronic intermittent hypoxia animal model / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 411-413, 2012.
Article Dans Chinois | WPRIM | ID: wpr-746801
ABSTRACT
OBJECTIVE@#To make a chronic intermittent hypoxia (CIH) animal model and explore the relationships of oxidative stress and the injury of aorta endothelial cell on the CIH rat model.@*METHOD@#Twenty-four sex maturation rat were randomly Divided into unhandled control group(normal feeding for 4 weeks, UC group), CIH group (CIH for 4 weeks), reoxygenation group (normal feeding for 4 weeks after CIH for 4 weeks, RH group). Determined the activity of superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) in blood serum of all groups. Dislodged rat's aorta, observed the appearance of aorta endothelial cell and the expression of endothelial nitric oxide synthase (eNOS).@*RESULT@#Compared with UC group, in CIH group the activities of SOD and NO were significantly lower, but MDA significantly higher (all of P 0.05).@*CONCLUSION@#Oxidative stress played a role in the injury of aorta endothelial cell on ob chronic intermittent hypoxia rat modle.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Aorte / Physiologie / Superoxide dismutase / Sang / Répartition aléatoire / Stress oxydatif / Cellules endothéliales / Modèles animaux de maladie humaine / Nitric oxide synthase type III / Malonaldéhyde Limites du sujet: Animaux langue: Chinois Texte intégral: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Année: 2012 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Aorte / Physiologie / Superoxide dismutase / Sang / Répartition aléatoire / Stress oxydatif / Cellules endothéliales / Modèles animaux de maladie humaine / Nitric oxide synthase type III / Malonaldéhyde Limites du sujet: Animaux langue: Chinois Texte intégral: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Année: 2012 Type: Article