One case report of Rosai-Dorfman disease in nasal cavity and nasal sinuses / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

Rosai-Dorfman disease in nasal cavity and nasal sinuses is known as an idiopathic proliferative disease of histiocytes with a distinct morphologic feature and is very rare. It is easy to relapse and be misdiagnosed. In on case, the infiltrating histiocytes had large round or oval nuclei. The cytoplasm was abundant, granular or vacuolated and foamy. Immunohistochemical studies showed that the histiocytes were strongly reactive with antibodies against S100 and CD68. The diagnosis of extranodal RDD in the paranasal sinuses could be differentiated with rhinoscleroma, eosinophilic granuloma, plasmacytoma, or fibrous histiocytoma. It showed that the identification of the distinctive histiocytes which are typically immunoreactive to S100 and CD68 can be quite helpful for correct diagnosis.