Nasal mucosa remodeling in chronic rhinosinusitis without nasal polyps / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To explore the feature of nasal mucosa remodeling in chronic rhinosinusitis without nasal polyps (CRSsNP).@*METHOD@#Histological specimens from 30 selected patients with CRSsNP who underwent endoscopic sinus surgery and 10 control subjects were studied. The paraffin sections were stained with hematoxylin-eosin(HE), alcian blue-periodic acid-Schiff (AB-PAS), Masson trichrome (MT) and Picric acid-Sirius red. The damage of epithelium, goblet cells and gland hyperplasia, deposition of collagen in extracellular matrix, the thickness of basement membrane and the type of collagen were observed respectively.@*RESULT@#Grade 0, Grade 1, Grade 2 and Grade 3 of epithelial damage were significantly different in the CRSsNP group when compared with the control group (P < 0.01 or P < 0.05). Evident mucus gland hyperplasia and collagen deposition in extracellular matrix were observed in CRSsNP group (P < 0.01). The number of goblet cells and the thickness of basement membrane were increased obviously in CRSsNP group (P < 0.01). The collagen deposited in extracellular matrix was mainly composed of collagen type I. Collagen type III and collagen type IV was much less than collagen type I.@*CONCLUSION@#The nasal mucosa remodeling was observed in CRSsNP group and was characterized by epithelial damage, basement membrane thickening, deposition of collagen in extracellular matrix, goblet cells and mucus gland hyperplasia.