Different expression of histamine H4 receptor in nasal mucosa in allergic rhinitis patients / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 928-930, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-747502
ABSTRACT
OBJECTIVE@#To observe expression and distribution of histamine H4 receptor in nasal mucosa in normal people and allergic rhinitis patients,and understand role of histamine H4 receptor in allergic rhinitis.@*METHOD@#Select normal people and allergic rhinitis patients each 10, take the nasal mucosa, detect expression and distribution of histamine H4 receptor at proteins and transcription level respectively by immunohistochemical method and RT-PCR, and compared.@*RESULT@#Histamine H4 receptor at proteins and transcription level were found in normal nasal mucosa (25 509 +/- 6 441, 0.42 +/- 0.08), increased significantly in nasal mucosa of allergic rhinitis patients (49 676 +/- 8 541, 0.69 +/- 0.11, P < 0.05), which in structural cells and immune cells.@*CONCLUSION@#Histamine H4 receptors exist in normal nasal mucosa, its express significantly enhance, flew histamine H4 receptor may be mediated histamine in pathogenesis of allergic rhinitis ,who is one of the ligands of histamine.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Récepteurs histaminergiques
/
Études cas-témoins
/
Rhinite spasmodique apériodique
/
Récepteurs couplés aux protéines G
/
Allergie et immunologie
/
Récepteur histaminergique H4
/
Métabolisme
/
Muqueuse nasale
Type d'étude:
Étude observationnelle
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Année:
2010
Type:
Article
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