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Effect of topical corticosteroids on expression of PKC, Bcl-2 and Bax in nasal polyps / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 772-775, 2010.
Article Dans Chinois | WPRIM | ID: wpr-747914
ABSTRACT
OBJECTIVE@#To study the effect of intranasal glucosteroid on the expression of PKC, Bcl-2 and Bax in nasal polyps.@*METHOD@#The expression of PKC, Bcl-2 protein and Bax were detected with immunohistochemistry in nasal polyps from the patients (n=16) pre and post treated for 4 weeks with intranasal glucosteroid. And which compared with normal mucous membrane of inferior turbinate concha.@*RESULT@#The PKC and Bcl-2 protein expressed significantly higher in the pretreated patients (P < 0.01), which were significant reduced in the post treated patients compared with pretreated ones. The expression of Bax protein significantly higher in the post treated patients (P < 0.05).@*CONCLUSION@#Our findings indicated that abnormal expression of apoptosis related genes in nasal polyps tissues might play an important role in the occurrence and progression of nasal polyps. The treatment of intranasal glucosteroid may regulate the expression of apoptosis related genes.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Protéine kinase C / Administration par voie nasale / Polypes du nez / Protéines proto-oncogènes c-bcl-2 / Utilisations thérapeutiques / Traitement médicamenteux / Protéine Bax / Glucocorticoïdes / Métabolisme Limites du sujet: Adolescent / Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Chinois Texte intégral: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Année: 2010 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Protéine kinase C / Administration par voie nasale / Polypes du nez / Protéines proto-oncogènes c-bcl-2 / Utilisations thérapeutiques / Traitement médicamenteux / Protéine Bax / Glucocorticoïdes / Métabolisme Limites du sujet: Adolescent / Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Chinois Texte intégral: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Année: 2010 Type: Article