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Expression of DcR3 protein and its significance in laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 537-539, 2007.
Article Dans Chinois | WPRIM | ID: wpr-748379
ABSTRACT
OBJECTIVE@#To investigate the expression of DcR3 in laryngeal carcinoma and analyze the relation between DcR3 and clinical factors.@*METHOD@#The expression of DcR3 protein in 41 laryngeal carcinoma tissues and 41 para-carcinoma tissues (to cutting margin > 0.5 cm) were measured by Flow Cytometer(Epics-XL II), 15 normal laryngeal mucosa tissues were served as controls.@*RESULT@#(1) The quantitative and qualitative expression of DcR3 protein in laryngeal carcinoma tissues was obviously higher than those in para-carcinoma and normal laryngeal mucosa tissues, respectively (P < 0.05). There was no significant difference for the DcR3 protein expression between para-carcinoma and normal laryngeal mucosa tissues. (2) In laryngeal carcinoma, the expression of DcR3 protein was not significantly related to clinical classification, tumor size, smoking history, patients' age and sex but related to metastasis, pathological grade and clinical stage.@*CONCLUSION@#The high level of DcR3 expression may contribute to the carcinogenesis and development of laryngeal carcinoma. So it can be an important index for judging the differentiation, infiltration, metastasis and staging of laryngeal carcinoma.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pronostic / Carcinomes / Tumeurs du larynx / Membre-6b de la superfamille des récepteurs au TNF / Métabolisme / Stadification tumorale Type d'étude: Étude pronostique / Recherche qualitative Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Chinois Texte intégral: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Année: 2007 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pronostic / Carcinomes / Tumeurs du larynx / Membre-6b de la superfamille des récepteurs au TNF / Métabolisme / Stadification tumorale Type d'étude: Étude pronostique / Recherche qualitative Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Chinois Texte intégral: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Année: 2007 Type: Article