Changing the paradigm for cough: does 'cough hypersensitivity' aid our understanding?
Asia Pacific Allergy
;
(4): 3-13, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-749977
ABSTRACT
Chronic cough is a common reason for patients to seek medication attention. Over the last few decades, we have experienced significant clinical success by applying the paradigm of 'evaluating and treating the causes for chronic cough'. However, we still ask ourselves 'what underlies chronic cough. Indeed in a considerable proportion of patients cough is idiopathic, or unexplained despite vigorous evaluation. Commonly associated conditions such as rhinitis, eosinophilic bronchitis, asthma, or gastroesophageal acidic reflux may not be fundamental to cough, and thus may be triggers rather than causes. The cardinal feature of chronic cough is persistent upregulation the cough reflex, which may be driven by complex interactions between biologic, neurologic, immunologic, genetic, comorbid, and environmental factors. We suggest the new paradigm 'cough hypersensitivity syndrome' should finally bring us further advances in understanding and management of chronic cough.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Réflexe
/
Hypersensibilité respiratoire
/
Asthme
/
Bronchite
/
Régulation positive
/
Rhinite
/
Toux
/
Granulocytes éosinophiles
/
Hypersensibilité
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Asia Pacific Allergy
Année:
2014
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS