Pale nasal mucosa affects airflow limitations in upper and lower airways in asthmatic children
Asia Pacific Allergy
;
(4): 220-225, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-750080
ABSTRACT
BACKGROUND:
Severe asthmatics are thought to have severer rhinitis than mild asthmatics. A pale nasal mucosa is a typical clinical finding in subjects with severe allergic rhinitis.OBJECTIVE:
The aim of this study was to investigate whether a pale nasal mucosa affects airflow limitations in the upper and lower airways in asthmatic children.METHODS:
Rhinomanometry, nasal scraping, and spirometry were performed in 54 asthmatic children (median age, 10 years). The nasal mucosa was evaluated by an otolaryngologist. Thirty-seven patients were treated with inhaled corticosteroids, and 11 patients were treated with intranasal corticosteroids.RESULTS:
Subjects with a pale nasal mucosa (n = 23) exhibited a lower nasal airflow (p < 0.05) and a larger number of nasal eosinophils (p < 0.05) in the upper airway as well as lower pulmonary functional parameters (p < 0.05 for all comparisons), i.e., the forced vital capacity (FVC), the forced expiratory volume in 1 second, and the peak expiratory flow, compared with the subjects who exhibited a normal or pinkish mucosa (n = 31). No significant difference in the forced expiratory flow between 25%–75% of the FVC, regarded as indicating the peripheral airway, was observed between the 2 groups.CONCLUSION:
A pale nasal mucosa may be a predictor of eosinophil infiltration of the nasal mucosa and central airway limitations in asthmatic children. When allergists observe a pale nasal mucosa in asthmatic children, they should consider the possibility of airflow limitations in not only the upper airway, but also the lower airway.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Asthme
/
Spirométrie
/
Obstruction nasale
/
Rhinite
/
Capacité vitale
/
Volume expiratoire maximal par seconde
/
Hormones corticosurrénaliennes
/
Rhinomanométrie
/
Granulocytes éosinophiles
/
Rhinite allergique
Type d'étude:
Étude pronostique
Limites du sujet:
Enfant
/
Humains
langue:
Anglais
Texte intégral:
Asia Pacific Allergy
Année:
2016
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS