Reconstruction of the Transmitral Flow Rate Curve with M-Mode,2-Dimensional and Doppler Echocardiography -Validation Study-

ABSTRACT

To validate ventricular diastolic phase parameters of reconstructed transmitral flow rate curve by M-mode, 2-dimensional and pulsed Doppler Echocardiography, these parameters were compared with same parameters by left ventriculography. The study population was 22 patients who received both coronary arteriography and echocardiographic examination. Transmitral flow rate curve and left ventricular filling volume curve were reconstructed from transmitral flow velocity curve by pulsed Doppler, mitral annulus diameter by two diameter by two dimensional and diastolic motion of both mitral leafltes by M-mode echocardiography. From left ventriculography, left ventricular filling volume curve and transmitral flow rate curve were made using area-length method by Sandler and Dodge. From trasmitral flow fraction, 1/2 diastolic time filling fraction, normalized peak filling volume, 1/3 diastolic time filling fraction, 1/2 diastolic time fraction, normalized peak early filling rate and ratio of early to late peak filling rate were measured. Correlation between same parameters derived from echocardiography and left ventriculography were observed. 1) Total diastolic filling volumecorrelation coefficient r=0.47, P<0.05. 2) 1/3 diastolic time filling fractioncorrelation coefficient r=0.90, P<0.001. 3) 1/2 diastolic time filling fractioncorrelation coefficient r=0.80, P<0.001. 4) Normalized peak early filling ratecorrelation coefficient r=0.57, P<0.01. 5) Ratio of early to late peak filling ratecorrelation coefficient r=0.85, P<0.001. Therefore, left ventricular diastolic phase parameters of reconstructed transmitral flow rate curve using, M-mode, 2-dimensional and pulsed Doppler echocardiography seems to be useful for the noninvasive evaluation of the left ventricular diastolic function.