Mechanism of regional selective brain damage in neonatal bilirubin encephalopathy / 国际儿科学杂志

ABSTRACT

Neonatal bilirubin encephalopathy is a common clinical neonatal disease.Brain damage caused by hyperbilirubinemia endangers children's lives or causes permanent neurological sequelae,which seriously affects children's health.It has been evidenced that the pathogenesis of neonatal bilirubin encephalopathy is related to changes in neurotoxicity,brain metabolism,neurotransmitters,immunity and glial cells caused by unconjugated bilirubin.Brain injury induced by unconjugated bilirubin has regional selectivity,which plays an important role in the pathogenesis of neonatal bilirubin encephalopathy and bilirubin brain injury.This article reviews the mechanism of regional selective brain damage in neonatal bilirubin encephalopathy.