Advances in the study of microRNA-7 involved in the injury and repair of intestinal epithelial barrier via EGFR / 国际儿科学杂志

ABSTRACT

MicroRNAs (miRNAs) are non-coding single-stranded small RNAs composed of 19 ～25 nucleotides involved in various life processes such as cell proliferation,differentiation,apoptosis,signal transduction and immune regulation at the post-transcriptional level.So it has become one of the research hotspots in recent years.Among them,MiR-7 is considered to be an important regulator of epithelial cell damage and repair.As the largest epithelium of the human body,the intestinal macosal epithelium is the link between the human body and the outside world,and plays an important role in the homeostasis of the internal environment.Numerous studies have shown that MiR-7 plays an irreplaceable role in intestinal epithelial barrier damage and repair through the epidermal growth factor receptor (EGFR)-related signal pathway.This paper reviews the research progress.