Correlation factor analysis of poor prognosis in patients with acute solitary pontine infarction / 临床神经病学杂志

ABSTRACT

Objective To analyze the influence factors of poor prognosis in acute solitary pontine infarction. Methods The maximal diameter of the infarct lesion, arterial blood supply distribution and perforating artery atherosclerosis in 73 acute solitary pontine infarction patints were examined by brain MRI. The intracranial vascular stenosis was assessed by brain MRA or CTA. Carotid ultrasound was used to evaluate the atherosclerosis of extracranial artery. According to the mRS score, patients were divided into poor prognosis group ( mRS score≥3) and good prognosis group ( mRS score <3). Results Compared with those in good prognosis group, the rate of diabetes, admission and discharge NIHSS score, early progress rate, fasting blood glucose level in poor prognosis group were significantly higher,and the ratio of males was significantly lower (P<0. 05 -0. 01). Compared with those in good prognosis group, incidence of infarction with multiple blood supply, perforators atherosclerosis, vertebral basilar artery stenosis ratio and maximum diameter of infarction in poor prognosis group were significantly higher (all P<0. 01). The lesion which extended from the deep part of the pontine to the ventral side of the pontine and basilar artery stenosis were independent predictors of poor prognosis in patients with acute solitary pontine infarction (OR=22. 137, 95% CI2. 563 -191. 228, P=0. 005; OR=28. 552, 95% CI2. 347 -347. 313, P=0. 009). Conclusion Perforating artery atherosclerosis and basilar artery stenosis are independent predictors of poor prognosis in patients with acute solitary pontine infarction.