Relationship between chronic renal injury and white matter hypertensity, enlarged perivascular spaces in elderly patients / 临床神经病学杂志

ABSTRACT

Objective To study the relationship between chronic renal injury and white matter hypertensity (WMH), enlarged perivascular spaces (EPVS) in elderly patients.Methods A total of 133 inpatients from 2015 to 2016 without clinical histories of stroke underwent brain MRI scan were enrolled.The degree of WMH and EPVS were evaluated according to Flair and T 2 MRI, respectively.Clinical characteristics including disease history , glomerular filtration rate ( eGFR), urine albumine／creatine ratio ( UACR ) and so on were compared between different degrees of WMH or EPVS.A logistic regression analysis was applied for further analysis.Results Compared with WMH scoring 0 -1 group, eGFR of WMH scoring 2 -3 group was significantly decreased , while UACR was significantly increased ( all P＜0.001).Compared with EPVS scoring 0 -1 group, eGFR of EPVS scoring 2-3 group was significantly decreased , while UACR was significantly increased (all P＜0.001).Logistic regression analysis showed that low eGFR and high UACR were independent risk factors for WMH and EPVS (all P＜0.05).Conclusion Chronic renal injury could be the independent risk factor of higher degree of WMH and EPVS , which would be potential for clinical use.