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Effect of real-time continuous monitoring system on serum inflammatory factors and prognosis in patients with sepsis / 中华内分泌外科杂志
Chinese Journal of Endocrine Surgery ; (6): 245-248, 2019.
Article Dans Chinois | WPRIM | ID: wpr-751993
ABSTRACT
Objective To investigate the effect of real-time continuous monitoring system(RT-CGMS)on serum inflammatory factors and prognosis in patients with sepsis.Methods According to the prospective studies,patients were randomly divided into two groups Patients with sepsis were randomly divided into real-time continuous monitoring of blood glucose group and monitoring blood glucose meter group,of which the fasting serum tumor necrosis factor alpha(TNF-α) and interleukin-6(IL-6) and high sensitive C reactive protein (hs-CRP) were detected on the 1st,3rd,7th day.Meanwhile,insulin dosage,incidence of hypoglycemia and mortality rate of 28 days of patients in two groups were recorded,and the above indexes were analyzed.Results TNF-α,IL-6 and hs-CRP in the real-time continuous blood glucose monitoring group were (16.12±2.42)pg/ml、(112.37±17.39)pg/ml and(19.62±2.72)mg/L on the 7th day respectively,while TNF-α,IL-6 and hs-CRP in the blood glucose monitoring group were(23.46±3.12)pg/ml、(140.19±21.48)pg/ml and(25.42±2.54)mg/L on the 7th day,respectively.The decrease of TNF-α,IL-6 and hs-CRP in the continuous blood glucose monitoring group was more significant than that in the blood glucose monitoring group (P<0.05).Insulin dosage in real-time continuous blood glucose monitoring group was (90.62±15.79)u,hypoglycemia rate was 5.4%,fatality rate was 10.81% in 28 days of hospitalization,insulin dosage was (130.59±20.65)u,hypoglycemia rate was 22.85%,and fatality rate was 31.42% in 28 days of hospitalization.There was significant difference between the two groups(P<0.05).Conclusion For sepsis patients with stress hyperglycemia,a real-time continuous monitoring system combined with insulin therapy can improve the inflammatory response,and control blood glucose effectively as well as reduce mortality.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude observationnelle / Étude pronostique langue: Chinois Texte intégral: Chinese Journal of Endocrine Surgery Année: 2019 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude observationnelle / Étude pronostique langue: Chinois Texte intégral: Chinese Journal of Endocrine Surgery Année: 2019 Type: Article