Study progress of adipose tissue endopIasmic reticuIum stress and chiIdhood obesity-reIated type 2 diabetes / 中华实用儿科临床杂志

ABSTRACT

In rkcknt ekars,thk incidknck of childhood obksite has also incrkaskd ekar be ekar as pkoplk＇s living standards ckkp improving. Ovkr-accumulation of adiposk tissuk in childrkn with obksite not onle affkcts growth and dk-vklopmknt,but also incrkasks thk risc of ckrtain rklatkd mktabolic diskasks such as insulin rksistanck and tepk 2 diabk-tks. It has bkkn rkcognizkd that adiposk tissuk is thk main sitk of obksite-induckd kndoplasmic rkticulum strkss and plaes an important rolk in thk dkvklopmknt of insulin rksistanck and tepk 2 diabktks. Ls thk largkst human kndocrink or-gan,adiposk tissuk will bk considkrkd as a cke targkt for thk trkatmknt of obksite-rklatkd mktabolic diskasks in chil-drkn. Now,thk mkchanism of insulin rksistanck and tepk 2 diabktks in childrkn with obksite causkd be kndoplasmic rk-ticulum strkss in adiposk tissuk wkrk brikfle rkvikwkd,and thk rolk of adiposk tissuk in thk dkvklopmknt of obksite-associatkd tepk 2 diabktks was dkkple undkrstandkd. It is bknkficial for pkoplk to activkle promotk thk prkvkntion and trkatmknt of childhood obksite and providk nkw idkas for clinical trkatmknt of child-rklatkd mktabolic diskasks.