Drug‐induced hypersensitivity syndrome / 中国小儿急救医学

ABSTRACT

Drug‐induced hypersensitivity syndrome is also known as drug reaction with eosinophilia and systemic symptoms which is a rare and serious adverse drug reaction. The clinical manifestations include skin eruption,hematologic abnormalities,lymphadenopathy,and internal organ involvement ( liver,kidney, lung) . Its pathogenesis is still unclear and is considered to be related to a variety of factors,including drug‐specific immune responses,viral reactivation and inheritance. Prompt withdrawal of suspicious drugs is the key to treatment,and the use of systemic corticosteroids and intravenous immunoglobulins remains contro‐versial.