Plasma levels of miRNA-145 and miRNA-19b in patients with acute heart failure and its clinical signifi-cance / 心血管康复医学杂志

ABSTRACT

Objective:To explore plasma levels of microRNA (miRNA)-145 and miRNA-19b in patients with acute heart failure (AHF) and its clinical significance .Methods: A total of 150 AHF patients ,who were treated in our hospital from Jan 2015 to Dec 2016 ,were selected as AHF group .Another 100 healthy subjects were regarded as healthy control group .According to NYHA classification ,AHF group was further divided into class III group (n＝67) and class IV group (n＝ 83 ).Left ventricular ejection fraction (LVEF) ,pulmonary arterial pressure (PAP) , plasma levels of brain natriuretic peptide (BNP) ,miRNA-145 and miRNA-19b were measured and compared among all groups.Results: Compared with healthy control group ,there were significant reductions in LVEF [ (78-57 ± 5-12)% vs.(49-32 ± 8-17)%] and PAP [(74-16 ± 10-82) mmHg vs.(28-35 ± 8-11) mmHg] ,and significant rise in plasma levels of BNP [ (51-84 ± 3-08) pg／ml vs .(204-15 ± 30-46) pg／ml] ,miRNA-145 [ (1-04 ± 0-27) vs. (2-42 ± 1-18)] and miRNA-19b [ (1-06 ± 0-25) vs.(4-53 ± 1-47)] in AHF group , P＝0-001 all.Compared with NYHA class III group ,there were significant rise in plasma levels of miRNA-145 [(1-47 ± 0-32) vs.(2-52 ± 0-46)] and miRNA-19b [(2-08 ± 0-56) vs.(4-62 ± 0-76)] in class IV group ,P＝0-001 both .Conclusion: Plasma levels of miRNA-145 and miRNA-19b increase in AHF patients along with heart failure aggravates ,which can be used as pre-dictive indexes for severity of heart failure .