Influence of tirofiban‐assisted PCI on serum sST2 and PTX‐3 levels in patients with acute ST‐segment elevation myocardial infarction／ / 心血管康复医学杂志

ABSTRACT

To explore therapeutic effect of tirofiban‐assisted percutaneous coronary intervention (PCI) on patients with acute ST‐segment elevation myocardial infarction (STEMI) and its influence on serum levels of soluble stromelysin 2 (sST2) and pentraxin (PTX)‐3. Methods: A total of 146 STEMI patients treated in our hospital from 2014 to 2017 were randomly and equally divided into pure PCI group and combined treatment group (received tirofi‐ ban and PCI ) , both groups received aspirin and clopidogrel for 7d after PCI .After treatment , TIMI blood flow grade , serum levels of sST2 and PTX‐3 , LVEDd and LVEF and incidence of major adverse cardiovascular events (MACE) were observed and compared between two groups .Results: After treatment , percentage of TIMI＜grade 3 in combined treatment group was significantly lower than that of pure PCI group (13. 7% vs.34. 2%, P＝0.003 ?).Compared with pure PCI group , there was significant rise in LVEF [ (54.34 ± 6.57 )% vs.(61.42 ± 7.31)%] and significant reductions in LVEDd [ (49. 35 ± 3.13) mm vs.(43.54 ± 3. 44) mm] after six months , ser‐um levels of sST2 [ (57.42 ± 8.93) μg／L vs .(35. 22 ± 8. 53) μg／L] and PTX‐3 [ (0.64 ± 0.11) μg／L vs.(0. 43 ± 0.09) μg／L] after one month in combined treatment group , P＝0. 001 all.During six‐month follow‐up , total inci‐dence rate of MACE in combined treatment group was significantly lower than that of pure PCI group (2. 7% vs. 24.7%, P＝0. 001).Conclusion: Tirofiban‐assisted PCI is beneficial for improving cardiac function , reducing ser‐um sST2 and PTX‐3 levels and incidence rate of MACE in STEMI patients after PCI , which is worth extending .24