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Association study of MTHFR C677T polymorphism and birth body mass with risk of autism / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science ; (12): 673-677, 2019.
Article Dans Chinois | WPRIM | ID: wpr-754182
ABSTRACT
Objective To explore the association of MTHFR C677T polymorphism and birth body mass with the vulnerability of autism in Chinese Han population. Methods Totally 1 505 children with au-tism have been recruited,using the diagnosis and statistical manual,4th revised version ( DSM-IV-R) diag-nostic criteria for autism. And 1 308 healthy control subjects sex matched with the children with autism were enrolled for the study. All the participants were identified the birth body mass ( kg) according to the birth medical recording. All the subjects were examined the MTHFR C677T genotypes,using the polymerase chain reaction- restrict fragment length polymorphism (PCR-RFLP) methods. The frequencies of genotypes,alleles and birth body mass were compared between autism and healthy control groups using the chi-square and other tests. Results The MTHFR C677T (P=0. 004,OR=1. 18,95% CI=1. 02-1. 29),low birth body mass (<2. 5 kg) (P=0. 001,OR=1. 04,95%CI=1. 02-1. 06),and their interactive effects ( P=0. 0001,OR=2. 18,95%CI=1. 44-3. 32) were associated with the vulnerability of autism. Conclusions The MTHFR C677T polymorphism,low birth body mass and their interactive effects might be associated with susceptibility of autism in Chinese Han population.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Etude d'étiologie / Guide de pratique / Étude pronostique langue: Chinois Texte intégral: Chinese Journal of Behavioral Medicine and Brain Science Année: 2019 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Etude d'étiologie / Guide de pratique / Étude pronostique langue: Chinois Texte intégral: Chinese Journal of Behavioral Medicine and Brain Science Année: 2019 Type: Article