Pigmentary Changes Following Photodynamic Therapy with 5-aminolevulinic Acid or Methyl Aminolevulinate Cream / 대한피부과학회지
Korean Journal of Dermatology
;
: 604-611, 2015.
Article
Dans Coréen
| WPRIM
| ID: wpr-7553
ABSTRACT
BACKGROUND:
Several side effects such as pain, erythema, and hyperpigmentation have been reported following photodynamic therapy (PDT).OBJECTIVE:
We sought to compare the pigmentary changes induced by PDT with 5-aminolevulinic acid (ALA) and those induced by PDT with methyl aminolevulinate (MAL) in people with skin phototypes III-IV over a 6 month period.METHODS:
In ten healthy volunteers, six skin areas on the upper arm of each subject were treated with (A) ALA 20% in base cream without irradiation, (A1) MAL 16.8% without irradiation, (B), (B1) control vehicles, (C) ALA 20% in base cream, and (C1) MAL 16.8%. Areas (B), (B1), (C), and (C1) were irradiated at four hours after photosensitizer or vehicle application. Irradiation was administered twice with a 1 week interval. The effects on the skin were assessed by visual and colorimetric evaluations.RESULTS:
On (C) and (C1) areas, erythema and pigmentation were most pronounced at 30 minutes after the second irradiation. Erythema rapidly diminished but pigmentation persisted throughout the study. Erythema and pigmentation on (C)-treated areas were more prominent and prolonged than those on (C1)-treated areas.CONCLUSION:
In subjects with skin phototypes III-IV, pigmentation tends to last for more than 6 months after PDT. The ALA-treated skin areas developed more severe and prolonged erythema and pigmentation than the MAL-treated skin areas.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Photothérapie dynamique
/
Bras
/
Peau
/
Pigmentation
/
Hyperpigmentation
/
Érythème
/
Volontaires sains
langue:
Coréen
Texte intégral:
Korean Journal of Dermatology
Année:
2015
Type:
Article
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