Two Distinxt Apoptotic Pathway in Human Monocytes Mediated by IL-4 and Fas / 대한면역학회지
Korean Journal of Immunology
;
: 405-410, 1998.
Article
Dans Coréen
| WPRIM
| ID: wpr-75543
ABSTRACT
Apoptosis has ernerged as a key mechanism for regulating the number of leukocytes at sites of inflammation. Besides withdrawal of inflammatory stimuli, apoptosis of human monocytes can be directly triggered through two cell surface molecules, Fas and the IL-4 receptor. In contrast to Fas-mediated death which utilizes reactive oxygen intermediates (ROI) as instruments of death, IL-4-induced apoptosis of monocytes was neither blocked by antioxidants, nor accompanied by elevation of cellular ROI. Moreover, PMA which upregulates protein kinase C (PKC) inhibited IL-4-, but not Fas-mediated death. These data define a ROl-dependent, PKC-resistant Fas pathway, and a ROl-independent, PKC-susceptible IL-4 pathway of apoptosis. Monocyte apoptosis triggered by depletion of inflammatory mediators resembles the IL-4 pathway. Within the context of an inflammatory site, monocyte accumulation and depletion may be susceptible to manipulation through these pathways.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oxygène
/
Protéine kinase C
/
Monocytes
/
Interleukine-4
/
Apoptose
/
Récepteurs à l'interleukine-4
/
Inflammation
/
Leucocytes
/
Antioxydants
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Immunology
Année:
1998
Type:
Article
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