Effect of deep brain stimulation on Parkinson's disease non-motor symptoms / 中华神经科杂志

ABSTRACT

Deep brain stimulation (DBS) has been widely recognized for improving motor symptoms of Parkinson's disease,but its effect on non-motor symptoms is still unclear.This article reviews recent DBS-related studies and discusses the effects of DBS treatment on non-motor symptoms,including olfaction,depression,cognition,sleep,and pain.Current studies find that the impact of DBS on olfactory functions and depression is not clear.DBS may increase the suicide rate in postoperative patients,and the rising suicide rate could stem from the reduction of postoperative levodopa equivalent dosage.DBS shows no significant impairment on cognition,and postoperative cognitive decline of patients may result from the progression of Parkinson's disease.DBS may ameliorate insomnia,but could worsen restless legs syndrome and rapid eye movement sleep behavior disorder.In addition,DBS may help to relieve Parkinson's disease-related pain,but the mechanism of improvement is yet to be clarified.