Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment
Protein & Cell
;
(12): 896-925, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-756982
ABSTRACT
Chimeric antigen receptor (CAR) is a recombinant immunoreceptor combining an antibody-derived targeting fragment with signaling domains capable of activating cells, which endows T cells with the ability to recognize tumor-associated surface antigens independent of the expression of major histocompatibility complex (MHC) molecules. Recent early-phase clinical trials of CAR-modified T (CAR-T) cells for relapsed or refractory B cell malignancies have demonstrated promising results (that is, anti-CD19 CAR-T in B cell acute lymphoblastic leukemia (B-ALL)). Given this success, broadening the clinical experience of CAR-T cell therapy beyond hematological malignancies has been actively investigated. Here we discuss the basic design of CAR and review the clinical results from the studies of CAR-T cells in B cell leukemia and lymphoma, and several solid tumors. We additionally discuss the major challenges in the further development and strategies for increasing anti-tumor activity and safety, as well as for successful commercial translation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Thérapeutique
/
Transplantation
/
Protéines de fusion recombinantes
/
Récepteurs aux antigènes des cellules T
/
Lymphocytes T
/
Leucémie-lymphome lymphoblastique à précurseurs B
/
Allergie et immunologie
/
Immunité cellulaire
/
Immunothérapie
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Protein & Cell
Année:
2017
Type:
Article
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