LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor
Protein & Cell
;
(12): 99-107, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-757115
ABSTRACT
Lung cancer is featured with high mortality, with a 15% five-year survival rate worldwide. Genetic alterations, such as loss of function of tumor suppressor genes, frequently contribute to lung cancer initiation, progression and metastasis. Liver kinase B1 (LKB1), as a serine/threonine kinase and tumor suppressor, is frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Recent studies have provided strong evidences that LKB1 loss promotes lung cancerigenesis process, especially lung cancer progression and metastasis. This review will summarize recent progress on how LKB1 modulates the process of lung cancerigenesis, emphasizing on LKB1 downstream signaling pathways and biological functions. We will further discuss the potential development of prognostic biomarkers or therapeutic targets in lung cancer clinic based on the molecular alteration associated with deregulated LKB1 signaling.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Transduction du signal
/
Protein-Serine-Threonine Kinases
/
Carcinome pulmonaire non à petites cellules
/
Évolution de la maladie
/
Protéines suppresseurs de tumeurs
/
Génétique
/
Tumeurs du poumon
/
Métabolisme
/
Métastase tumorale
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Protein & Cell
Année:
2011
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS