The role of galectin-4 in physiology and diseases
Protein & Cell
;
(12): 314-324, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-757132
ABSTRACT
Galectin-4, a tandem repeat member of the β-galactoside-binding proteins, possesses two carbohydrate-recognition domains (CRD) in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various ligands. Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes. Recent evidence shows that galectin-4 plays an important role in lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, tumor progression, etc. This article reviews the physiological and pathological features of galectin-4 and its important role in such processes.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Axones
/
Cicatrisation de plaie
/
Sang
/
Maladies inflammatoires intestinales
/
Microdomaines membranaires
/
Galectine 4
/
Endocytose
/
Génétique
/
Métabolisme
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Protein & Cell
Année:
2016
Type:
Article
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