DNA sensor cGAS-mediated immune recognition
Protein & Cell
;
(12): 777-791, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-757365
ABSTRACT
The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogenic DNAs are supposed to be detected by DNA sensors that induce the activation of NFκB or TBK1-IRF3 pathway. DNA sensor cGAS is widely expressed in innate immune cells and is a key sensor of invading DNAs in several cell types. cGAS binds to DNA, followed by a conformational change that allows the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) from adenosine triphosphate and guanosine triphosphate. cGAMP is a strong activator of STING that can activate IRF3 and subsequent type I interferon production. Here we describe recent progresses in DNA sensors especially cGAS in the innate immune responses against pathogenic DNAs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Liaison aux protéines
/
ADN bactérien
/
ADN viral
/
Transduction du signal
/
Interféron de type I
/
Modèles moléculaires
/
Régulation de l'expression des gènes
/
Facteur de transcription NF-kappa B
/
Protein-Serine-Threonine Kinases
/
Allergie et immunologie
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Protein & Cell
Année:
2016
Type:
Article
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