Nucleosome assembly and epigenetic inheritance
Protein & Cell
;
(12): 820-829, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-757436
ABSTRACT
In eukaryotic cells, histones are packaged into octameric core particles with DNA wrapping around to form nucleosomes, which are the basic units of chromatin (Kornberg and Thomas, 1974). Multicellular organisms utilise chromatin marks to translate one single genome into hundreds of epigenomes for their corresponding cell types. Inheritance of epigenetic status is critical for the maintenance of gene expression profile during mitotic cell divisions (Allis et al., 2006). During S phase, canonical histones are deposited onto DNA in a replication-coupled manner (Allis et al., 2006). To understand how dividing cells overcome the dilution of epigenetic marks after chromatin duplication, DNA replication coupled (RC) nucleosome assembly has been of great interest. In this review, we focus on the potential influence of RC nucleosome assembly processes on the maintenance of epigenetic status.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Histone
/
Nucléosomes
/
Chimie
/
Structure quaternaire des protéines
/
Assemblage et désassemblage de la chromatine
/
Épigenèse génétique
/
Réplication de l'ADN
/
Génétique
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Protein & Cell
Année:
2010
Type:
Article
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