Proton transfer-mediated GPCR activation
Protein & Cell
;
(12): 12-17, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-757629
ABSTRACT
G-protein coupled receptors (GPCRs) play essential roles in signal transduction from the environment into the cell. While many structural features have been elucidated in great detail, a common functional mechanism on how the ligand-binding signal is converted into a conformational change on the cytoplasmic face resulting in subsequent activation of downstream effectors remain to be established. Based on available structural and functional data of the activation process in class-A GPCRs, we propose here that a change in protonation status, together with proton transfer via conserved structural elements located in the transmembrane region, are the key elements essential for signal transduction across the membrane.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Protons
/
Transduction du signal
/
Chimie
/
Motifs d'acides aminés
/
Récepteurs couplés aux protéines G
/
Potentiels de membrane
/
Protéines membranaires
/
Métabolisme
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Protein & Cell
Année:
2015
Type:
Article
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