USP33, a new player in lung cancer, mediates Slit-Robo signaling
Protein & Cell
;
(12): 704-713, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-757656
ABSTRACT
Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Physiologie
/
Pronostic
/
Immunohistochimie
/
Récepteurs immunologiques
/
Transduction du signal
/
Régulation négative
/
Régulation de l'expression des gènes tumoraux
/
Mouvement cellulaire
/
Technique de Western
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Protein & Cell
Année:
2014
Type:
Article
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