The role of BRCA1 in DNA damage response
Protein & Cell
;
(12): 117-123, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-757722
ABSTRACT
BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de l'ovaire
/
Physiologie
/
Altération de l'ADN
/
Tumeurs du sein
/
Transduction du signal
/
Gènes suppresseurs de tumeur
/
Apoptose
/
Gènes cdc
/
Protéine BRCA1
/
Réparation de l'ADN
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Protein & Cell
Année:
2010
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS