Changes in the thyroid hormone profiles in children with nephrotic syndrome / 소아과
Korean Journal of Pediatrics
;
: 85-89, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-760190
ABSTRACT
PURPOSE:
We compared thyroid hormone profiles in children with nephrotic syndrome (NS) during the nephrotic phase and after remission.METHODS:
This study included 31 pediatric NS patients. The thyroid hormone profiles included serum levels of triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), and free T4.RESULTS:
Of the 31 patients, 16 (51.6%) showed abnormal thyroid hormone profiles 6 had overt hypothyroidism, 8 had subclinical hypothyroidism, and 2 had low T3 syndrome. The mean serum T3, T4, and free T4 levels in the nephrotic phase and after remission were 82.37±23.64 and 117.88±29.49 ng/dL, 5.47±1.14 and 7.91±1.56 µg/dL, and 1.02±0.26 and 1.38±0.23 ng/dL, respectively; the levels were significantly lower in the NS nephrotic phase (P=0.0007, P<0.0001, and P=0.0002). The mean serum TSH levels during the nephrotic phase and after remission were 8.05±3.53 and 4.08±2.05 µIU/ mL, respectively; they were significantly higher in the nephrotic phase (P=0.0005). The urinary protein/ creatinine ratio during the nephrotic phase was significantly correlated with serum T3, T4, and free T4 levels (r=-0.5995, P=0.0032; r=-0.5797, P=0.0047; r=-0.5513, P=0.0078) as well as with TSH levels (r=0.5022, P=0.0172). A significant correlation was found between serum albumin and serum T3 levels during the nephrotic phase (r=0.5385, P=0.0018) but not between serum albumin and T4, TSH, or free T4 levels. These significant correlations all disappeared after remission.CONCLUSION:
Abnormal thyroid hormone profile findings were observed in 51.6% of pediatric patients with NS. Thyroid hormone levels normalized after remission, regardless of levothyroxine therapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Glande thyroide
/
Hormones thyroïdiennes
/
Thyroxine
/
Tri-iodothyronine
/
Syndrome euthyroïdien
/
Sérumalbumine
/
Thyréostimuline
/
Créatinine
/
Hypothyroïdie
/
Syndrome néphrotique
Limites du sujet:
Enfant
/
Humains
langue:
Anglais
Texte intégral:
Korean Journal of Pediatrics
Année:
2019
Type:
Article
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