Pituitary magnetic resonance imaging abnormalities in young female patients with hypogonadotropic hypogonadism
Obstetrics & Gynecology Science
; : 249-257, 2019.
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| ID: wpr-760650
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ABSTRACT
OBJECTIVE: To elucidate the association between clinical and laboratory characteristics and pituitary magnetic resonance imaging (MRI) abnormalities in young female patients with hypogonadotropic hypogonadism (HH). METHODS: We retrospectively investigated a series of 74 female patients (age range, 14–42 years) with normoprolactinemic HH who underwent pituitary MRI. Pubertal milestones and hormonal features of patients with small pituitary glands (PGs) and space-occupying lesions were compared with those of patients with normal PGs. RESULTS: The overall frequency of abnormal PGs was 35.1%, with space-occupying lesions observed in 8 patients (10.8%), and small PG observed in 18 patients (24.3%). The mean serum gonadotropin level was not different between patients with and without pituitary MRI abnormalities (P>0.05). Space-occupying lesions were not associated with low gonadotropin levels, type of amenorrhea, or presence of secondary sex characteristics. The frequency of space-occupying lesions was higher in patients with interrupted puberty (25.0%) than in patients who did not go through puberty (4.8%) or had a normal puberty (9.8%), but were not statistically significant (P>0.05). Small PG was associated with low gonadotropin levels and type of amenorrhea (P<0.05). CONCLUSION: Clinically significant space-occupying lesions were not associated with low gonadotropin levels, type of amenorrhea, or presence of secondary sex characteristics. However, the frequency of space-occupying lesions was higher in patients with interrupted puberty than in patients who did not go through puberty or who with normal puberty.
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Indice:
WPRIM
Sujet Principal:
Hypophyse
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Retard pubertaire
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Imagerie par résonance magnétique
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Études rétrospectives
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Puberté
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Caractères sexuels
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Aménorrhée
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Gonadotrophines
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Hypogonadisme
Type d'étude:
Observational_studies
Limites du sujet:
Adolescent
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Female
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Humans
langue:
En
Texte intégral:
Obstetrics & Gynecology Science
Année:
2019
Type:
Article