Expression of Metabotropic Glutamate Receptors in the Medial Vestibular Nucleus Following Acute Hypotension in Rats / 대한평형의학회지
Journal of the Korean Balance Society
;
: 131-137, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-761125
ABSTRACT
BACKGROUND AND OBJECTIVES:
Acute hypotension induces expression of c-Fos protein and phosphorylated extracellular signal-regulated kinase (pERK), and glutamate release in the vestibular nuclei. Expression of c-Fos protein and pERK is mediated by the excitatory neurotransmitter, glutamate. In this study, the signaling pathway of glutamate in the vestibular nuclei following acute hypotension was investigated. MATERIALS ANDMETHODS:
Expression of metabotropic glutamate receptors (mGluRs) was measured by Western blotting in the medial vestibular nucleus following acute hypotension in rats.RESULTS:
Expression of pGluR1 Ser831, a subtype of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, peaked at 30 minutes after acute hypotension insult, and expression of pNR2B, a subtype of N-methyl-D-aspartate (NMDA) receptors, peaked at 2 hours after acute hypotension insult. Acute hypotension induced expression of Homer1a and group I mGluR in the medial vestibular nucleus. Expression of mGluR1 and mGluR5 peaked at 6 hours following acute hypotension insults.CONCLUSION:
These results suggest that afferent signals from the peripheral vestibular receptors, resulting from acute hypotension insult, are transmitted through group I mGluRs as well as AMPA and NMDA receptors in the vestibular system.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phosphotransferases
/
Noyaux vestibulaires
/
Technique de Western
/
N-Méthyl-aspartate
/
Récepteurs du N-méthyl-D-aspartate
/
Récepteurs métabotropes au glutamate
/
AMPA
/
Agents neuromédiateurs
/
Acide glutamique
/
Hypotension artérielle
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Journal of the Korean Balance Society
Année:
2012
Type:
Article
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