Understanding the pharmacokinetics of reversible metabolism
Translational and Clinical Pharmacology
;
: 52-58, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-761935
ABSTRACT
This tutorial introduces the mathematical skills required to obtain exact and approximate solutions for reversible reactions and provides graphical insights to help understand the pharmacokinetics of reversible metabolism. The matrix method provides an easy way to derive the exact solution for the amount of each species as a function of time. The plots of the exact solutions reveal some characteristic features of the pharmacokinetic profiles of the reversible metabolism. We also describe two approximation approaches, steady-state approximation, and equilibrium approximation, to simplify the solutions. The skills and knowledge acquired through this tutorial will provide a basis for understanding more complex reversible reaction systems.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacocinétique
/
Métabolisme
/
Méthodes
langue:
Anglais
Texte intégral:
Translational and Clinical Pharmacology
Année:
2019
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS