Collective exposure to lead from an approved natural product-derived drug in Korea
Annals of Occupational and Environmental Medicine
;
: e20-2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-762558
ABSTRACT
BACKGROUND:
In Asian countries, including Korea, lead poisoning caused by traditional herbal medicines is often observed in the clinic. However, there have been no reports thus far of lead poisoning caused by drugs that were approved by the Korea Food and Drug Administration (KFDA). Here, we describe seven patients who ingested a problematic natural product-derived drug (NPD). CASE PRESENTATION In July 2018, seven patients visited a university hospital after ingesting an NPD, S. capsules. These patients complained of various symptoms, and their blood lead levels (BLLs) were elevated relative to those of the general population (arithmetic mean 19.5 ± 11.6 µg/dL, range 6.28–35.25 µg/dL). The total doses and BLLs were directly proportional to each other among the patients (r = 0.943, p = 0.001). After the patients discontinued drug intake, their BLLs decreased gradually. The capsule was confirmed to contain lead above the standard value (arithmetic mean 2,547 ± 1,821.9 ppm).CONCLUSION:
This incident highlights the need to strengthen standards for the management of NPD ingredients in Korea. NPDs are more likely to be contaminated than other drugs. Thorough management by the KFDA is essential to prevent a recurrence. Moreover, systematic health care is needed for many patients who have taken problematic NPDs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Récidive
/
Food and Drug Administration (USA)
/
Capsules
/
Prestations des soins de santé
/
Asiatiques
/
Corée
/
Intoxication par le plomb
Type d'étude:
Guide de pratique
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Annals of Occupational and Environmental Medicine
Année:
2019
Type:
Article
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