Your browser doesn't support javascript.
loading
The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age
Asia Pacific Allergy ; (4): e33-2019.
Article Dans Anglais | WPRIM | ID: wpr-762876
ABSTRACT

BACKGROUND:

Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship.

OBJECTIVE:

We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period.

METHODS:

We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2–4 years.

RESULTS:

The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2–4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184–2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135–1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood OR, 1.242; 95% CI, 0.353–4.368; for 1-year peripheral-blood OR, 1.451; 95% CI, 0.428–4.919).

CONCLUSION:

There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Asthme / Maladies des bronches / Études de cohortes / Études de suivi / Télomère / Stress oxydatif / Parturition / Hypersensibilité / Leucocytes Type d'étude: Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Enfant d'âge préscolaire / Humains langue: Anglais Texte intégral: Asia Pacific Allergy Année: 2019 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Asthme / Maladies des bronches / Études de cohortes / Études de suivi / Télomère / Stress oxydatif / Parturition / Hypersensibilité / Leucocytes Type d'étude: Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Enfant d'âge préscolaire / Humains langue: Anglais Texte intégral: Asia Pacific Allergy Année: 2019 Type: Article