The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age
Asia Pacific Allergy
;
(4): e33-2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-762876
ABSTRACT
BACKGROUND:
Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship.OBJECTIVE:
We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period.METHODS:
We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2–4 years.RESULTS:
The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2–4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184–2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135–1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood OR, 1.242; 95% CI, 0.353–4.368; for 1-year peripheral-blood OR, 1.451; 95% CI, 0.428–4.919).CONCLUSION:
There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Asthme
/
Maladies des bronches
/
Études de cohortes
/
Études de suivi
/
Télomère
/
Stress oxydatif
/
Parturition
/
Hypersensibilité
/
Leucocytes
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Enfant d'âge préscolaire
/
Humains
langue:
Anglais
Texte intégral:
Asia Pacific Allergy
Année:
2019
Type:
Article
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