Survival and Prognosis of Patients with Pilocytic Astrocytoma: A Single-Center Study
Brain Tumor Research and Treatment
;
: 92-97, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-763109
ABSTRACT
BACKGROUND:
Pilocytic astrocytoma (PA) is a brain tumor that is relatively more common in children and young adults.METHODS:
We retrospectively reviewed the medical records of patients with PA treated at a single center between 1988 and 2018.RESULTS:
We included 31 subjects with PA. The median age at diagnosis was 13.4 years, and the median follow-up duration was 9.9 years. The total PA group had a 10-year disease-specific survival (DSS) rate of 92.6% [95% confidence interval (CI), 82.6–100] and 10-year progression-free survival (PFS) rate of 52.8% (95% CI, 32.0–73.6). In patients aged <20 years, tumors were more likely to be located in sites in which gross total tumor resection (GTR) was impossible. No statistically significant difference in 10-year DSS was found between the GTR (100%) and non-GTR (89.7%; 95% CI, 76.2–100; p=0.374) groups. However, a statistically significant difference in 10-year PFS was found between the GTR (100%) and non-GTR groups (30.7%; 95% CI, 8.6–52.8; p=0.012). In the non-GTR group, no statistically significant difference in 10-year DSS was found between the patients who received immediate additional chemotherapy and/or radiotherapy (Add-Tx group, 92.9%; 95% CI, 79.4–100) and the non-Add-Tx group (83.3%; 95% CI, 53.5–100; p=0.577). No statistically significant difference in 10-year PFS was found between the Add-Tx group (28.9%; 95% CI, 1.7–56.1) and non-Add-Tx group (33.3%; 95% CI, 0–70.9; p=0.706).CONCLUSION:
The PFS of the patients with PA in our study depended only on the degree of surgical excision associated with tumor location. This study is limited by its small number of patients and retrospective nature. A multicenter and prospective study is necessary to confirm these findings.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Radiothérapie
/
Astrocytome
/
Tumeurs du cerveau
/
Dossiers médicaux
/
Études prospectives
/
Études rétrospectives
/
Études de suivi
/
Survivants
/
Survie sans rechute
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Enfant
/
Humains
langue:
Anglais
Texte intégral:
Brain Tumor Research and Treatment
Année:
2019
Type:
Article
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