Cognitive Therapy Combined with Drug Treatment in Patients with Alzheimer's Disease: A Neuropsychological and Positron Emission Tomography Investigation, a Pilot Study
Dementia and Neurocognitive Disorders
;
: 76-82, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-76325
ABSTRACT
BACKGROUND:
Cognitive therapy may have therapeutic benefit in patients with early Alzheimer's disease (AD). CASE REPORT This was a 12-week, single-blind pilot study of 4 patients with AD. The cognitive therapy included exercises for orientation to time and place; memory training, including face-name association, object recall training, and spaced retrieval; visuo-motor organization using software; similarity and ruled based categorization; and behavior modification and sequencing (e.g., making change, paying bills). The regional cerebral metabolic abnormalities and the effects of treatment on cortical metabolic responses were evaluated using 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (PET). After 12 weeks, the participants showed slight improvement in some neuropsychological measures, and three of them showed increased regional cortical metabolism on brain PET studies.CONCLUSIONS:
Cognitive therapy may stabilize or improve cognitive and functional performance of patients with early AD and increase regional cortical metabolism of the patients' brain.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thérapie comportementale
/
Encéphale
/
Exercice physique
/
Thérapie cognitive
/
Projets pilotes
/
Tomographie par émission de positons
/
Maladie d'Alzheimer
/
Apprentissage
/
Métabolisme
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Dementia and Neurocognitive Disorders
Année:
2015
Type:
Article
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