Investigation of the association of idiopathic male infertility with polymorphisms in the methionine synthase (MTR) gene / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
; : 107-111, 2019.
Article
de En
| WPRIM
| ID: wpr-763364
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: Spermatogenesis is a complex process that is regulated by a number of genes, some of which are involved in folate-dependent 1-carbon metabolism. Methionine synthase (encoded by MTR) is a key enzyme participating in this pathway. This study aimed to investigate the relationship of the MTR 2756A > G polymorphism with idiopathic male fertility in the Iranian population. METHODS: The participants of this study included 100 men with idiopathic infertility and 100 healthy men as the control group. Genotyping of MTR 2756A > G was performed using the polymerase chain reaction and restriction fragment length polymorphism technique. The obtained data were analyzed using SPSS ver. 20.0 with a level of confidence of p G single-nucleotide polymorphism is not a predisposing factor for idiopathic infertility in men.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Spermatogenèse
/
5-Methyltetrahydrofolate-homocysteine s-methyltransferase
/
Polymorphisme de restriction
/
Réaction de polymérisation en chaîne
/
Causalité
/
Allèles
/
Fécondité
/
Génotype
/
Infertilité
/
Infertilité masculine
Type d'étude:
Prognostic_studies
Limites du sujet:
Humans
/
Male
langue:
En
Texte intégral:
Clinical and Experimental Reproductive Medicine
Année:
2019
Type:
Article