Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
Diabetes & Metabolism Journal
;
: 549-559, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-763691
ABSTRACT
Obesity results in an inflammatory microenvironment in adipose tissue, leading to the deterioration of tissue protective mechanisms. Although recent studies suggested the importance of type 2 immunity in an anti-inflammatory microenvironment in adipose tissue, the regulatory effects of T helper 2 (Th2) cytokines on systemic metabolic regulation are not fully understood. Recently, we identified the roles of the Th2 cytokine (interleukin 4 [IL-4] and IL-13)-induced adipokine, growth differentiation factor 15 (GDF15), in adipose tissue in regulating systemic glucose metabolism via signal transducer and activator of transcription 6 (STAT6) activation. Moreover, we showed that mitochondrial oxidative phosphorylation is required to maintain these macrophage-regulating autocrine and paracrine signaling pathways via Th2 cytokine-induced secretion of GDF15. In this review, we discuss how the type 2 immune response and Th2 cytokines regulate metabolism in adipose tissue. Specifically, we review the systemic regulatory roles of Th2 cytokines in metabolic disease and the role of mitochondria in maintenance of type 2 responses in adipose tissue homeostasis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phosphorylation oxydative
/
Tissu adipeux
/
Cytokines
/
Communication paracrine
/
Facteur de transcription STAT-6
/
Adipokines
/
Facteur-15 de croissance et de différenciation
/
Glucose
/
Homéostasie
/
Maladies métaboliques
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Diabetes & Metabolism Journal
Année:
2019
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS