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Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium
Environmental Health and Toxicology ; : e2019004-2019.
Article Dans Anglais | WPRIM | ID: wpr-763723
ABSTRACT
Disinfectants including polyhexamethylene guanidine phosphate (PHMG) and mixtures of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) have been widely used in Korea to prevent microbial growth in the humidifier water, which triggered an outbreak of serious respiratory diseases. In addition to the respiratory syndrome, disease-related symptoms including liver toxicity, asthma, and skin allergies were also found after extensive survey of people exposed to the humidifier disinfectants (HDs). In this study, eye irritation tests were performed based on the Organization for economic co-operation and development (OECD) test guidelines 492 using EpiOcular™ which is a tissue model of reconstructed human cornea-like epithelium. As results, the raw materials of PHMG (26% as active ingredient) and CMIT/MIT (1.5% as active ingredient) were classified under UN globally harmonized system of classification and labeling of chemical (GHS) category 1 or category 2. However, aqueous dilutions of raw materials such as market products of HDs that contain 0.13% of PHMG and 0.03% of CMIT/MIT or further dilutions of the market products for humidifier that contain 0.0013% of PHMG and 0.0003% of CMIT/MIT were classified under any category, which suggested absence of eye irritation at the test concentration.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Asthme / Peau / Nations Unies / Eau / Classification / Guanidine / Désinfectants / Épithélium / Humidificateurs / Hypersensibilité Type d'étude: Recherche qualitative Limites du sujet: Humains Pays comme sujet: Asie langue: Anglais Texte intégral: Environmental Health and Toxicology Année: 2019 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Asthme / Peau / Nations Unies / Eau / Classification / Guanidine / Désinfectants / Épithélium / Humidificateurs / Hypersensibilité Type d'étude: Recherche qualitative Limites du sujet: Humains Pays comme sujet: Asie langue: Anglais Texte intégral: Environmental Health and Toxicology Année: 2019 Type: Article