Clinical effect of montelukast in exercise-induced asthma / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 720-727, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-76390
ABSTRACT
BACKGROUND:
Patients with bronchial asthma frequently have exercise-induced bronchocon striction. Exercise-induced bronchoconstriction limits the activities important for physical and social development in children. Leukotriene receptor antagonist has been shown to protect against exercise-induced bronchoconstriction. The purpose of this study is to determine the effect of montelukast in protecting or controlling exercise-induced asthma.METHOD:
22 patients were enrolled and received montelukast(5 mg/day) for 2 months. Exercise challenges were performed before and after treatment and medication was not given for at least 48 hours before follow-up test. The form of exercise was free running for 8 minutes. The respiratory symptom scores, maximum percent fall in FEV1 from pre-exercise baseline and time to recovery of FEV1 to within 10% of pre-exercise baseline were evaluated.RESULTS:
The respiratory symptoms score was siginificantly improved after 2 months of therapy(p<0.05). The maximum percent fall in FEV1 after exercise and the time from maximum percent fall in FEV1 to return to within 10 precent of pre-exercise FEV1 were also siginificantly improved after 2 months of therapy(p<0.05). In 3 patients with exercise-induced asthma, the maximum percent fall in FEV1 was decreased after 2 months of therapy, but was increased after follow-up 2 months without therapy.CONCLUSION:
Montelukast, a leukotriene-receptor antagonist, is effective for protection and control of exercise-induced asthma in children.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Asthme
/
Asthme à l'effort
/
Course à pied
/
Changement social
/
Études de suivi
/
Bronchoconstriction
/
Récepteurs aux leucotriènes
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Enfant
/
Humains
langue:
Coréen
Texte intégral:
Journal of Asthma, Allergy and Clinical Immunology
Année:
2002
Type:
Article
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