Effects of Dexmedetomidine Infusion During Sevoflurane Anesthesia on Otoacoustic Emissions
Journal of Audiology & Otology
;
: 89-95, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-764209
ABSTRACT
BACKGROUND AND OBJECTIVES:
Knowing the ototoxic potential of the agents used in medical treatments is important for the protection of hearing. Although we have knowledge regarding some effects of dexmedetomidine, which is an anesthetic-sparing drug, its influence over the hearing system has never been studied and is obscure yet. The aim of this study is to determine the effects of intravenous dexmedetomidine application during sevoflurane anesthesia on otoacoustic emissions (OAEs). SUBJECTS ANDMETHODS:
This prospective randomized study was performed on 60 patients (34 male, 26 female, mean age 30.6±9.2 years) who were scheduled for an elective surgery under general anesthesia and the patients were enrolled and randomly divided into 2 groups. They received dexmedetomidine (Group D) or Saline (Group S) infusion during a standardized Sevoflurane anesthesia. Transient and distortion product OAEs were measured preoperatively and postoperatively (24th hour). OAE results were compared within and between groups.RESULTS:
In group D postoperative OAEs were lower than preoperative OAEs and postoperative levels of group S, especially at low frequencies (p<0.05).CONCLUSIONS:
Dexmedetomidine infusion affects the micromechanical function of cochlea especially in the low-frequency region. Dexmedetomidine should be carefully used during general anesthesia to avoid its probable harmful effects on cochlear micromechanics.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Études prospectives
/
Cochlée
/
Dexmédétomidine
/
Agonistes des récepteurs alpha-2 adrénergiques
/
Ouïe
/
Anesthésie
/
Anesthésie générale
Type d'étude:
Essai clinique contrôlé
/
Étude observationnelle
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Journal of Audiology & Otology
Année:
2019
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS